clinical translation in nanomedicine and drug delivery

Nanoparticle delivery systems are gaining traction in their clinical utility and are investigated for the delivery of chemotherapeutic drugs, siRNAs and other agents, and also as diagnostic and imaging applications. Physicochemical properties of nanoparticles play an important role in their biological performance. Nanoparticles of various sizes, shapes, elasticities, and surface chemistries are becoming more widely used; however, this presents a number of translational challenges from a materials point of view. Specifically, as nanoparticle delivery systems become more advanced, methods for their synthesis, scale-up, and characterization need to follow suit. Furthermore, as advancements in technology allow for precise control over all nanoparticle parameters, approaches to systematically analyze the effects these parameters have on nanoparticle performance are essential.

 

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