5th Annual Congress on Nanomedicine and Drug Delivery August 10-11, 2020 Bangkok, Thailand

Nanotechnology seems to have gained a widespread interest in the recent years. Nanotechnology has considerably accelerated the growth of regenerative medicine the past few years. Application of Nanotechnology in regenerative medicine has revolutionized the designing of grafts and scaffolds which has resulted in new grafts/scaffold systems having significantly enhanced cellular and tissue regenerative properties. Since the cell–cell and cell-matrix interaction in biological systems takes place at the nano scale level, the application of nanotechnology gives an edge in modifying the cellular function and/or matrix function in a more desired way to mimic the native tissue/organ. Nano medicine introduces Nanotechnology concepts into medicine and thus joins two large cross disciplinary fields with an unprecedented societal and economical potential arising from the natural combination of specific achievements in the respective fields.

Nanotechnology is universally recognized as one of the most important scientific fields of the twenty‐first century. Biomedical applications of this technology offer great promise in finding new approaches to repairing damaged tissues and curing disease. Nano medicine and Nano biotechnology will address key topics from the perspectives of medicine, biology, physics, chemistry, and engineering, and serve as an encyclopedic reference for Nano medicine and Nano biotechnology research.

Nano medicine will be based on the ability to build Nano robots. In the future these Nano robots could actually be programmed to repair specific diseased cells, functioning in a similar way to antibodies in our natural healing processes. The motivation for the new manipulation technology is the desire to enter the micro- and Nano world not only by viewing but also acting, altering micro- and nano sized objects. A new era on medicine are expected to happen in the coming years. Due to the advances in the field of Nanotechnology, Nano device manufacturing has been growing gradually. The elimination of bacterial infections in a patient within minutes, instead of using treatment with antibiotics over a period of weeks.

Some smart drug delivery platform is based on neutral phospholipid Nano liposomes. Where classic Classic liposomes modalities have had manufacturing problems involving sizing, uniformity, loading, storage, and enhancement compatibility, which can be overcome by employing true nanotechnology to build liposomes upon discrete self-assembling DNA scaffolds. The smart drug delivery system is used for delivering drugs to the host. Biological MEMS or NEMS technology based drug pumps, micro-pumps, micro-needles, micro-osmotic pumps, and information detected by biological sensors is analyzed and the drug delivery system is actuated to deliver the drug based on the information. nano-pumps are utilized for smarter drug delivery. One of the concerns these days about self-assembling nanotechnology is that it is so advanced beyond the current drug paradigm that it becomes problematic from a regulatory point of view. While there is currently no drug treatment delivered directly into these types of cancers.

Nano medicine is a branch of medicine that applies the knowledge and tools of nanotechnology in the prevention and treatment of diseases. Nano medicine involves the use of nano scale materials, such as biocompatible nanoparticles and Nano robots, for diagnosis, delivery, sensing or actuation purposes in a living organism. Nanoparticles with ~100 nano meters have been widely used to improve the drug accumulation, internalization and therapeutic efficacy. The physicochemical and biological properties of the Nanoparticles can also be finely adjusted by tailoring their chemical properties, sizes, shapes, structures, morphologies, and surface properties. Nano medicine is the medical application of Nanotechnology. Nanotechnology has provided the possibility of delivering drugs to specific cells using nanoparticles. Current problems for nano medicine involve understanding the issues related to toxicity and environmental impact of nano scale materials.

Nano medicine seeks to deliver a valuable set of research tools and clinically useful devices in the near future. The National Nanotechnology Initiative expects new commercial applications in the pharmaceutical industry that may include advanced drug delivery systems, new therapies, and in vivo imaging.

The computational studies in nanoparticles have demonstrated that there has been considerable progress in Nano and biotechnology in the last several years. However, several key challenges have also become apparent, including the need for a better understanding of nanoparticle behaviour in vivo and the development of more effective nanoparticle therapeutics. Computational efforts are becoming an important tool in addressing both of these challenges, as well as in generally facilitating and accelerating nanotechnology-based translational research. The Nano informatics has come out as a new research area that covers raw data management, analysis of the data derived from biomedical applications and simulation of nanoparticle interactions with biological systems depicting the integration of biology, nanotechnology and informatics to form the basis for computational Nanomedicine.

Nano medicine has been developing rapidly in recent years, particularly in the development of novel Nano tools for medical diagnosis and treatment. For instance,a new trend is becoming prevalent in developing Nano systems for simultaneous tumour diagnosis and therapy.A new terminology"Theranostics" has been frequently used and applied in pre-clinical research and trials. A Nano system can simultaneously achieve both cell targeted in vivo imaging and photo thermal treatment of cancer. While achieving concurrent high spatial and temporal resolution of the lesions via cell targeting; special non-evasive treatments are implemented at the same time by various means, such as localized drug release, hyperthermia, and photo-thermal therapy Inspired by these challenging problems in biomedical fields, the development of the nanotechnologies will be the key in addressing some of the critical issues in medicine, especially in early cancer diagnosis and treatment.

With the remarkable development of Nanotechnology in recent years, new drug delivery approaches based on the state-of-the-art nanotechnology have been receiving significant attention. Nanoparticles, an evolvement of nanotechnology,are increasingly considered as a potential candidate to carry therapeutic agents safely into a targeted compartment in an organ,particular tissue or cell.These particles are colloidal structures with a diameter less than 1,000 nm, and therefore can penetrate through diminutive capillaries into the cell’s internal machinery.This innovative delivery technique might be a promising technology to meet the current challenges in drug delivery.The different types of nanoparticles drug delivery systems under investigation and their prospective therapeutic applications, and also present a closer look at the advances,current challenges, and future direction of nanoparticles drug delivery systems.

The use of nano scale materials and processes to address human disease is perhaps the most promising, considering that most complex downstream symptoms of disease are initiated by molecular level phenomena. Nano medicine is defined as biological and medical intervention at the nano meter scale for the treatment, diagnosis, and increased understanding of biology and disease.Tremendous advances in the area of polymer synthesis and self-assembly have given rise to a new toolbox of engineered nano sized delivery and diagnostic agents that permit systemic and local administration, circulation in the bloodstream, and uptake and diffusion at the cellular and subcellular level.

Recent years have witnessed the rapid development of inorganic nano materials for medical applications. At present, nano medicines-nanoparticles (NPs) destined for therapy or diagnosis purposes-can be found in a number of medical applications, including therapeutics and diagnosis agents .Pushing the limits of nanotechnology towards enhanced Nano medicines will surely help to reduce side effects of traditional treatments and to achieve earlier diagnosis. The interplay between engineered nano materials and biological components is influenced by complex interactions which make predicting their biological fate and performance a nontrivial issue. We hope that both early-stage and experienced researchers will find it valuable for designing nanoparticles for enhanced bio-performance. Nano emulsions have attracted great attention in research, dosage form design and pharmacotherapy. This is as a result of a number of attributes peculiar to nano emulsions.

Nanotechnology is a rapidly growing field having potential applications in many areas. Nanoparticles have been studied for cell toxicity, immune toxicity, and geno toxicity. Tetra zolium-based assays such as MTT, MTS, and WST-1 are used to determine cell viability. Different types of cell cultures, including cancer cell lines have been employed as in vitro toxicity models. Considering the potential applications of NPs in many fields and the growing apprehensions of FDA about the toxic potential of Nano products, it is the need of the hour to look for new internationally agreed, free of bias toxicological models by focusing more on in vivo studies. The rapid expansion of nanotechnology promises to have great benefits for society, yet there is increasing concern that human and environmental exposure to engineered nano materials may result in significant adverse effects. The system was developed for Nano toxicity assessment at single and multiple cell levels which can measure and compare the microscopic and macroscopic effects of nanoparticles interaction with cells, without interference from neighbouring cells' cues and also overall integrative effects produced by nanoparticles and cell–cell communication.

Currently,the treatment of HIV requires regular oral dosage of HIV drugs, and chronic oral dosing has significant complications that arise from the high pill burden experienced by many patients across populations with varying conditions leading to non-adherence to therapies.Recent evaluation of HIV patient groups have shown a willingness to switch to nanomedicine alternatives if benefits can be shown.Research efforts by the Liverpool team have focused on the development of new oral therapies, using Solid Drug Nanoparticle(SDN)technology which can improve drug absorption into the body,reducing both the dose and the cost per dose and enabling existing healthcare budgets to treat more patients.

Formulation studies involve developing a preparation of the drug which is both stable and acceptable to the patient. For orally administered drugs, this usually involves incorporating the drug into a tablet or a capsule. It is important to make the distinction that a tablet contains a variety of other potentially inert substances apart from the drug itself, and studies have to be carried out to ensure that the encapsulated drug is compatible with these other substances in a way that does not cause harm, whether direct or indirect. Formulation studies also consider such factors as particle size, polymorphism, pH, and solubility, as all of these can influence bioavailability and hence the activity of a drug. The drug must be combined with inactive ingredients by a method which ensures that the quantity of drug present is consistent in each dosage unit e.g. each tablet. The dosage should have a uniform appearance, with an acceptable taste, tablet hardness, or capsule disintegration. By the time phase III clinical trials are reached, the formulation of the drug should have been developed to be close to the preparation that will ultimately be used in the market.

Pharmacy is the science and technique of preparing and dispensing drugs. It is a health profession that links health sciences with chemical sciences and aims to ensure the safe and effective use of pharmaceutical drugs. A theory relating chemical structure to pharmaceutical activity emerged from the interplay of experimental results from animal and human tests using vaccines, antitoxins, and antibodies with chemical knowledge about dyes and their molecular structures. Although pharmacology is essential to the study of pharmacy, it is not specific to pharmacy. Pharmaco informatics is considered as another new discipline, for systematic drug discovery and development with efficiency and safety. The progressively more important role of the chemist and chemical science in pharmaceuticals in the early-20th century is mirrored in the history of the American Chemical Society's Division of Medicinal Chemistry

Pharmacodynamics refers to the relationship between drug concentration at the site of action and the resulting effect, including the time course and intensity of therapeutic and adverse effects. The effect of a drug present at the site of achievement is determined by that drug’s binding with a receptor. Receptors may be present on neurons in the central nervous system (i.e., opiate receptors) to depress pain sensation, on cardiac muscle to affect the intensity of contraction, or even within bacteria to disrupt maintenance of the bacterial cell wall

Identifying drug targets plays essential roles in designing new drugs, drug formulations and combating diseases. Unfortunately, our current understanding about drug targets is far from comprehensive. Screening drug targets in the lab is an expensive and time-consuming procedure. In the past decade, the accumulation of various types of study of science related data makes it possible to develop computational approaches to predict drug targets. Non-communicable diseases such as cancer, atherosclerosis and diabetes are responsible for most important social and health affliction as millions of people are dying every year. Out of which, atherosclerosis is the leading cause of deaths worldwide. The lipid abnormality is one of the most important modifiable risk factors for atherosclerosis. Both genetic and environmental components are associated with the development of atherosclerotic plaques. Immune and inflammatory mediators have a complex role in the initiation and progression of atherosclerosis. Understanding of all these processes will help to invent a range of new biomarkers and novel treatment modalities targeting various cellular events in acute and chronic inflammation that are accountable for atherosclerosis. Several biochemical pathways, receptors and enzymes are involved in the development of atherosclerosis that would be possible targets for improving strategies for disease diagnosis and management.

Clinical Bio therapeutic aspects including study drug formulations, drug design, drug-drug interactions, QT assessment, immunogenicity, comparability, special populations (hepatic and liver failure), PK and PD, regulatory expectations of PK and PD characterization, as well as reviewing factors which influence the ADME of Bio therapeutics. The objectives of early clinical development of therapeutic proteins are the same as for small molecules i.e. to investigate the molecule in a manner that will gain necessary knowledge about its tolerability safety pharmacokinetics (PK) and if possible pharmacodynamics (PD) effects in the most appropriate human populations while simultaneously protecting their safety. However, there are specific features of proteins that must be considered when designing clinical pharmacology studies.